6/22/2023 0 Comments Caffeine half lifeIt seems that these components of cigarette smoke are the polycyclic aromatic hydrocarbons.Ĭigarette smoking accelerates the metabolism of certain drugs, particularly those primarily metabolized by cytochrome P450 1A2 (CYP1A2) and, to a lesser extent, CYP2E1 and some UDP-glucuronosyltransferases. There's also an interesting 2011 study on what exact components of cigarette smoke accelerate the clearance of caffeine. In fact that 2000 review lists Cimetidine in the opposite direction than Pharma Rev, which actually seems to be the correct one. grapefruit and some drugs), but I couldn't find any data specific to foods and caffeine, except for grapefruit, which does increase caffeine half-life too.įrom an older (2000) review on the same caffeine-drug interaction issue, it seems indeed that Omeprazole is the only drug with such a significant effect (well included in the review): I would not be surprised if some foods do the same (given the known interactions between e.g. There is a much longer list of drugs that increase the half-life of caffeine though (presumably mostly by competing on the P450 pathway). but again that seem to be an error because a primary study I found says:ĭuring the period of maximum inhibition the mean elimination half-life of caffeine increased from 5.6 hours at baseline to 57 hours after administration of methoxsalen The Pharma Rev source alas also claims that some anti-psoriasis / anti-eczema drugs decrease caffeine half-life, listing Methoxsalen (−70%) and 5-Methoxypsoralen (−31%). there is indeed increased/faster caffeine clearance on Omeprazole. Omeprazole has previously been shown to induce hepatic cytochrome P4501A2 activity, as evidenced by an accelerated N-3-demethylation in the 13C-caffeine breath test Ī review of PPIs (see table 3) confirms this with additional studies, i.e. ![]() During fluvoxamine, the median of the total clearance of caffeine decreased from 107 ml min-1 to 21 ml min-1 and the half-life increased from 5 to 31 hģ1 / 5 = 6.2 so they almost used this study as a ref, but misinterpreted the direction of the effect.īut their listing of PPIs effect on caffeine metabolism is probably correct a quick search found a paper tiled "Accelerated caffeine metabolism after omeprazole treatment " The selective serotonin reuptake inhibitor fluvoxamine is a very potent inhibitor of the liver enzyme CYP1A2, which is the major P450 catalysing the biotransformation of caffeine. And it seems they misinterpreted that study as Fluvoxamine is one of the more potent inhibitors of P450 pathway involved, actually having the opposite effect on caffeine half-life: ![]() Most other drugs in this class have the opposite effect on caffeine half-life. ![]() I would caution on using the claims that source without double-checking with the primary studies because they listed Fluvoxamine (an antidepressant) as −80% "decreases caffeine half-life by sixfold". (I think PPIs like Omeprazole are generally available without prescription.) ![]() Rev., but few drugs shorten the half-life of caffeine, mainly some (but not all) proton pump inhibitors ("heartburn" drugs) like Omeprazole (−41%) and Cimetidine (−31%). There is a more extensive list of caffeine-drug interactions in Pharma. out of the cigarette smoke components, it's the carcinogenic aromatic hydrocarbons and not the nicotine that's responsible for this interaction with caffeine.medication-wise, the OTC "heartburn" drug Omeprazole has been fairly consistently reported to have this effect (but many, many more drugs of various classes have the opposite effect).diet-wise brassica vegetables, in particular broccoli seems to have this effect (but other vegetables that share P450 inhibitors in common with citrus fruits have the opposite effect).
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